Transient myeloproliferative disorder in an infant with PTPN11 mutation
نویسندگان
چکیده
منابع مشابه
Down's syndrome with transient myeloproliferative disorder.
Children with Down's syndrome are at an increased risk for development of several hematological disorders like acute leukemia, acute myelofibrosis of childhood and transient myeloproliferative disorder (TMD)(1). Transient myeloproliferative disorder is recognized shortly after birth or in neonatal period and is characterized by leukocytosis and thrombocytopenia, which resolves spontaneously in ...
متن کاملTransient Myeloproliferative Disorder in Neonate with Suspected Down Syndrome
A female with suspected Down syndrome was born by vaginal delivery at 37 weeks 2 days’ gestation to a mother with a history of Type A2 gestational diabetes mellitus. Routine prenatal testing consisted of a non-invasive screening test for aneuploidy. Results, presented in Table 1, indicated an aneuploidy for trisomy of chromosome 21, indicating an increased risk for Down syndrome. Prenatal confi...
متن کاملTransient neonatal myeloproliferative disorder without Down syndrome and detection of GATA1 mutation.
Transient myeloproliferative disorder is a form of self-limited leukemia that occurs almost exclusively in neonates with Down syndrome. The authors report an unusual case of a newborn without constitutional trisomy 21 who developed undifferentiated leukemia and subsequently achieved clinical and molecular remission without chemotherapy. Cytogenetics and molecular analysis have shown trisomy 21 ...
متن کاملMonoclonal Blast Cell Proliferation in Transient Myeloproliferative Disorder
Transient myeloproliferative disorder is a hematological condition observed during the neonatal period in patients with Down syndrome [1]. This disorder mimics congenital leukemia and the blast cells were often reported to show characteristics compatible with those of megakaryoblasts [2] or pluripotent stem cells [3]. Although this disorder usually resolves gradually without antileukemic treatm...
متن کاملMYELOID NEOPLASIA Down syndrome and GATA1 mutations in transient abnormal myeloproliferative disorder: mutation classes correlate with progression to myeloid leukemia
1Department of Pediatrics, Hirosaki University Graduate School of Medicine, Hirosaki, Japan; 2Department of Hematology/Oncology, Gunma Children’s Medical Center, Gunma, Japan; 3Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan; 4Department of Pediatrics, Graduate School of Medicine, University of Toyama, Toyama, Japan; 5Department of Pediatrics, Kagoshima Ci...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: British Journal of Haematology
سال: 2017
ISSN: 0007-1048
DOI: 10.1111/bjh.14517